HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-(Trifluoromethoxy)benzaldehyde → 5-([1,1'-Biphenyl]-2-yl)-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-(Trifluoromethoxy)benzaldehyde | HCID 69573 | — |
| Reactant | Methyl 4-([1,1'-biphenyl]-2-yl)-4-aminobutanoate | HCID 69084601 | — |
| Product | 5-([1,1'-Biphenyl]-2-yl)-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-one | HCID 69083619 | — |
Reaction Steps
Prepared according to the described general procedure 2 (GP2) by reaction of methyl 4-([1,1′-biphenyl]-2-yl)-4-aminobutanoate with commercially available 4-(trifluoromethoxy)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.99 min.; [M+H]+: 411.89 g/mol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242970B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-75df54a036604439a20a4e4053afa07b |
| Source note | uspto-grants-2016_01 |