p-(Trifluoromethoxy)benzaldehyde → 5-([1,1'-Biphenyl]-2-yl)-3-methyl-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-one

Participants

Role	Name	HCID	Charge
Reactant	p-(Trifluoromethoxy)benzaldehyde	HCID 69573	—
Reactant	Ethyl 4-([1,1'-biphenyl]-2-yl)-4-amino-2-methylbutanoate	HCID 69082640	—
Product	5-([1,1'-Biphenyl]-2-yl)-3-methyl-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-one	HCID 69081667	—

Reaction Steps

Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-([1,1′-biphenyl]-2-yl)-4-amino-2-methylbutanoate with commercially available 4-(trifluoromethoxy)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=1.03 min.; [M+H]+: 425.99 g/mol.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09242970B2
Source dataset	uspto-grants-2016_01
ORD ID	ord-624a5db025da4d2786955f589938c365
Source note	uspto-grants-2016_01