4-(Trifluoromethoxy)benzylamine → HCID 69082449, compound

HRID 594679Notes

Reaction equation

HRID 594679 reaction equation
[F:1][C:2]([F:13])([F:12])[O:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][NH2:11])=[CH:6][CH:5]=1.[Cl:14][C:15]1[C:16]([O:25][CH3:26])=[C:17]([C:20]([O:23][CH3:24])=[CH:21][CH:22]=1)[CH:18]=O>>[Cl:14][CH:15]1[CH2:22][CH:18]([C:17]2[C:20]([O:23][CH3:24])=[CH:21][CH:22]=[C:15]([Cl:14])[C:16]=2[O:25][CH3:26])[N:11]([CH2:10][C:7]2[CH:6]=[CH:5][C:4]([O:3][C:2]([F:12])([F:13])[F:1])=[CH:9][CH:8]=2)[C:16]1=[O:25]

Participants

3

Reactant 2

HCID 5718464-(Trifluoromethoxy)benzylamineHCID 15414486HCID 15414486, compound

Product 1

HCID 69082449HCID 69082449, compound

Procedure

Prepared according to the described general procedures 10A2 (GP10A2), 10B (GP10B), 10F (GP10F), and 10D (GP10D) using commercially available (4-(trifluoromethoxy)phenyl)methanamine and synthesized 3-chloro-2,6-dimethoxybenzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.97 min.; [M+H]+: 463.84 g/mol.

Workup

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Sources & evidence

ORD record
ord-5bd65e5f15e94799978c26cbdb6dd6a5
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

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