4-(Trifluoromethoxy)benzylamine → HCID 69080846, compound

HRID 594681Notes

Reaction equation

HRID 594681 reaction equation
[F:1][C:2]([F:13])([F:12])[O:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][NH2:11])=[CH:6][CH:5]=1.[CH2:14]([O:16][C:17]1[C:24]([F:25])=[CH:23][CH:22]=[CH:21][C:18]=1[CH:19]=O)[CH3:15]>>[CH2:14]([O:16][C:17]1[C:24]([F:25])=[CH:23][CH:22]=[CH:21][C:18]=1[CH:19]1[N:11]([CH2:10][C:7]2[CH:6]=[CH:5][C:4]([O:3][C:2]([F:12])([F:13])[F:1])=[CH:9][CH:8]=2)[C:17](=[O:16])[CH:24]([F:25])[CH2:23]1)[CH3:15]

Participants

3

Reactant 2

HCID 5718464-(Trifluoromethoxy)benzylamineHCID 866956162-Ethoxy-3-fluorobenzaldehyde

Product 1

HCID 69080846HCID 69080846, compound

Procedure

Prepared according to the described general procedures 10A2 (GP10A2), 10B (GP10B), 10F (GP10F), and 10I (GP10I) using commercially available (4-(trifluoromethoxy)phenyl)methanamine and synthesized 2-ethoxy-3-fluorobenzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.95 min.; [M+H]+: 415.87 g/mol.

Workup

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Sources & evidence

ORD record
ord-4143a7c470fb4aaf8c7f6038faecf1cd
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

Loading…