HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(5-Methylthiazol-2-yl)benzaldehyde → 5-(2,4-Dimethoxypyridin-3-yl)-3-methyl-1-(3-(5-methylthiazol-2-yl)benzyl)pyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(5-Methylthiazol-2-yl)benzaldehyde | HCID 53273723 | — |
| Reactant | Methyl 4-amino-4-(2,4-dimethoxypyridin-3-yl)-2-methylbutanoate | HCID 69085168 | — |
| Product | 5-(2,4-Dimethoxypyridin-3-yl)-3-methyl-1-(3-(5-methylthiazol-2-yl)benzyl)pyrrolidin-2-one | HCID 69085355 | — |
Reaction Steps
Prepared according to the described general procedure 2 (GP2) by reaction of methyl 4-amino-4-(2,4-dimethoxypyridin-3-yl)-2-methylbutanoate with 3-(5-methylthiazol-2-yl)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.75 min.; [M+H]+: 423.87 g/mol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242970B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-e4e1da083cef4c568566bf56566325a7 |
| Source note | uspto-grants-2016_01 |