2-(4-Methylphenyl)-1,3-thiazole-4-carbaldehyde → 5-(2,4-Dimethoxypyridin-3-yl)-3-methyl-1-((2-(p-tolyl)thiazol-4-yl)methyl)pyrrolidin-2-one

Participants

Reaction Steps

Prepared according to the described general procedure 2 (GP2) by reaction of methyl 4-amino-4-(2,4-dimethoxypyridin-3-yl)-2-methylbutanoate with commercially available 2-(p-tolyl)thiazole-4-carbaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.82 min.; [M+H]+: 423.98 g/mol.

Provenance & Evidence