HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoate → 5-(2,6-Dimethoxyphenyl)-3-methyl-1-((2-(5-methylthiazol-2-yl)pyridin-4-yl)methyl)pyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoate | HCID 69085588 | — |
| Reactant | 2-(5-Methylthiazol-2-yl)isonicotinaldehyde | HCID 86695620 | — |
| Product | 5-(2,6-Dimethoxyphenyl)-3-methyl-1-((2-(5-methylthiazol-2-yl)pyridin-4-yl)methyl)pyrrolidin-2-one | HCID 86695657 | — |
Reaction Steps
Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoate with synthesized 2-(5-methylthiazol-2-yl)isonicotinaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.82 min.; [M+H]+: 424.03 g/mol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242970B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-60173505476c4ee590103baacad4576b |
| Source note | uspto-grants-2016_01 |