3-Phenylbenzaldehyde → 1-([1,1'-Biphenyl]-3-ylmethyl)-5-(2,4-dimethoxypyridin-3-yl)-3-methylpyrrolidin-2-one

Participants

Role	Name	HCID	Charge
Reactant	3-Phenylbenzaldehyde	HCID 121053	—
Reactant	Methyl 4-amino-4-(2,4-dimethoxypyridin-3-yl)-2-methylbutanoate	HCID 69085168	—
Product	1-([1,1'-Biphenyl]-3-ylmethyl)-5-(2,4-dimethoxypyridin-3-yl)-3-methylpyrrolidin-2-one	HCID 69083751	—

Reaction Steps

Prepared according to the described general procedure 2 (GP2) by reaction of methyl 4-amino-4-(2,4-dimethoxypyridin-3-yl)-2-methylbutanoate with commercially available [1,1′-biphenyl]-3-carbaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.85 min.; [M+H]+: 402.99 g/mol.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09242970B2
Source dataset	uspto-grants-2016_01
ORD ID	ord-1c75509d3c0f491689fda8813506b803
Source note	uspto-grants-2016_01