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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594693Generated: October 31, 2026

2-Quinolinecarboxaldehyde → 5-(2-Fluoro-6-methoxyphenyl)-3-methyl-1-(quinolin-2-ylmethyl)pyrrolidin-2-one

https://huagongshe.com/reaction/594693

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-QuinolinecarboxaldehydeHCID 79619—
ReactantEthyl 4-amino-4-(2-fluoro-6-methoxyphenyl)-2-methylbutanoateHCID 69085707—
Product5-(2-Fluoro-6-methoxyphenyl)-3-methyl-1-(quinolin-2-ylmethyl)pyrrolidin-2-oneHCID 69082791—

Reaction Steps

Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2-fluoro-6-methoxyphenyl)-2-methylbutanoate with commercially available quinoline-2-carbaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.65 min.; [M+H]+: 365.02 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-d5924dfa8a9341528f9e4926af657341
Source noteuspto-grants-2016_01