Ethyl 4-amino-4-(2-fluoro-6-methoxyphenyl)-2-methylbutanoate → HCID 69082801, compound

HRID 594695Notes

Reaction equation

HRID 594695 reaction equation
[NH2:1][CH:2]([C:11]1[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[CH:13][C:12]=1[F:19])[CH2:3][CH:4]([CH3:10])[C:5]([O:7]CC)=O.[N:20]1([C:25]2[CH:26]=[C:27]([CH:30]=[CH:31][N:32]=2)[CH:28]=O)[CH:24]=[CH:23][CH:22]=[N:21]1>>[N:20]1([C:25]2[CH:26]=[C:27]([CH2:28][N:1]3[CH:2]([C:11]4[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[CH:13][C:12]=4[F:19])[CH2:3][CH:4]([CH3:10])[C:5]3=[O:7])[CH:30]=[CH:31][N:32]=2)[CH:24]=[CH:23][CH:22]=[N:21]1

Participants

3

Reactant 2

HCID 69085707Ethyl 4-amino-4-(2-fluoro-6-methoxyphenyl)-2-methylbutanoateHCID 86695613HCID 86695613, compound

Product 1

HCID 69082801HCID 69082801, compound

Procedure

Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2-fluoro-6-methoxyphenyl)-2-methylbutanoate with 2-(1H-pyrazol-1-yl)isonicotinaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.79 min.; [M+H]+: 381.04 g/mol.

Workup

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Sources & evidence

ORD record
ord-1937b35775fd45cd8c12fd597f7f7fb4
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

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