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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594698Generated: November 1, 2026

3-(5-Methylthiazol-2-yl)benzaldehyde → 5-(2-Fluoro-6-methoxyphenyl)-3-methyl-1-(3-(5-methylthiazol-2-yl)benzyl)pyrrolidin-2-one

https://huagongshe.com/reaction/594698

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(5-Methylthiazol-2-yl)benzaldehydeHCID 53273723—
ReactantEthyl 4-amino-4-(2-fluoro-6-methoxyphenyl)-2-methylbutanoateHCID 69085707—
Product5-(2-Fluoro-6-methoxyphenyl)-3-methyl-1-(3-(5-methylthiazol-2-yl)benzyl)pyrrolidin-2-oneHCID 69085592—

Reaction Steps

Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2-fluoro-6-methoxyphenyl)-2-methylbutanoate with 3-(5-methylthiazol-2-yl)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.88 min.; [M+H]+: 411.00 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-0f5ac84868ce45999d501ee2c503e384
Source noteuspto-grants-2016_01