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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594703Generated: October 25, 2026

3-Fluoro-4-(trifluoromethoxy)benzaldehyde → 5-(2-Ethoxy-6-fluorophenyl)-1-(3-fluoro-4-(trifluoromethoxy)benzyl)-3-methylpyrrolidin-2-one

https://huagongshe.com/reaction/594703

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Fluoro-4-(trifluoromethoxy)benzaldehydeHCID 2783358—
ReactantEthyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoateHCID 69083532—
Product5-(2-Ethoxy-6-fluorophenyl)-1-(3-fluoro-4-(trifluoromethoxy)benzyl)-3-methylpyrrolidin-2-oneHCID 69083660—

Reaction Steps

Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoate with commercially available 3-fluoro-4-(trifluoromethoxy)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.98 min.; [M+H]+: 429.97 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-fd19b08752704f89a2aeb0827674ba71
Source noteuspto-grants-2016_01