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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594705Generated: October 25, 2026

3-(Difluoromethoxy)benzaldehyde → 1-(3-(Difluoromethoxy)benzyl)-5-(2-ethoxy-6-fluorophenyl)-3-methylpyrrolidin-2-one

https://huagongshe.com/reaction/594705

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Difluoromethoxy)benzaldehydeHCID 2736985—
ReactantEthyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoateHCID 69083532—
Product1-(3-(Difluoromethoxy)benzyl)-5-(2-ethoxy-6-fluorophenyl)-3-methylpyrrolidin-2-oneHCID 69081382—

Reaction Steps

Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoate with commercially available 3-(difluoromethoxy)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.90 min.; [M+H]+: 394.02 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-66762d6eb78e4948bcd9835ef209a24c
Source noteuspto-grants-2016_01