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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594707Generated: October 25, 2026

3-Ethoxybenzaldehyde → 5-(2-Ethoxy-6-fluorophenyl)-1-(3-ethoxybenzyl)-3-methylpyrrolidin-2-one

https://huagongshe.com/reaction/594707

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-EthoxybenzaldehydeHCID 89908—
ReactantEthyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoateHCID 69083532—
Product5-(2-Ethoxy-6-fluorophenyl)-1-(3-ethoxybenzyl)-3-methylpyrrolidin-2-oneHCID 69084515—

Reaction Steps

Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoate with commercially available 3-ethoxybenzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.92 min.; [M+H]+: 372.03 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-8fa82841ee294f60b7591a6be06b96a0
Source noteuspto-grants-2016_01