HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Propoxybenzaldehyde → 5-(2-Ethoxy-6-fluorophenyl)-3-methyl-1-(4-propoxybenzyl)pyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Propoxybenzaldehyde | HCID 79812 | — |
| Reactant | Ethyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoate | HCID 69083532 | — |
| Product | 5-(2-Ethoxy-6-fluorophenyl)-3-methyl-1-(4-propoxybenzyl)pyrrolidin-2-one | HCID 69084262 | — |
Reaction Steps
Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoate with commercially available 4-propoxybenzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.97 min.; [M+H]+: 385.81 g/mol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242970B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-ab53ebb30466422d99c5920987f72f69 |
| Source note | uspto-grants-2016_01 |