Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594715Generated: October 31, 2026

3-(5-Methylthiazol-2-yl)benzaldehyde → 5-(2-Ethoxy-6-fluorophenyl)-3-methyl-1-(3-(5-methylthiazol-2-yl)benzyl)pyrrolidin-2-one

https://huagongshe.com/reaction/594715

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(5-Methylthiazol-2-yl)benzaldehydeHCID 53273723—
ReactantEthyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoateHCID 69083532—
Product5-(2-Ethoxy-6-fluorophenyl)-3-methyl-1-(3-(5-methylthiazol-2-yl)benzyl)pyrrolidin-2-oneHCID 69084410—

Reaction Steps

Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoate with 3-(5-methylthiazol-2-yl)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.92 min.; [M+H]+: 425.02 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-f452bb841e8c4a178f01c0f35d17dc54
Source noteuspto-grants-2016_01