HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoate → 1-(3-(4-Chlorothiazol-2-yl)benzyl)-5-(2-ethoxy-6-fluorophenyl)-3-methylpyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoate | HCID 69083532 | — |
| Reactant | 3-(4-Chlorothiazol-2-yl)benzaldehyde | HCID 86695618 | — |
| Product | 1-(3-(4-Chlorothiazol-2-yl)benzyl)-5-(2-ethoxy-6-fluorophenyl)-3-methylpyrrolidin-2-one | HCID 69084412 | — |
Reaction Steps
Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoate with 3-(4-chlorothiazol-2-yl)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.97 min.; [M+H]+: 444.95 g/mol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242970B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-d40b8c372a314472b01cd093131457b6 |
| Source note | uspto-grants-2016_01 |