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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594728Generated: October 25, 2026

3-Fluoro-4-(trifluoromethoxy)benzaldehyde → 5-(2,6-Dimethoxyphenyl)-1-(3-fluoro-4-(trifluoromethoxy)benzyl)-3-methylpyrrolidin-2-one

https://huagongshe.com/reaction/594728

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Fluoro-4-(trifluoromethoxy)benzaldehydeHCID 2783358—
ReactantEthyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoateHCID 69085588—
Product5-(2,6-Dimethoxyphenyl)-1-(3-fluoro-4-(trifluoromethoxy)benzyl)-3-methylpyrrolidin-2-oneHCID 69083472—

Reaction Steps

Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoate with commercially available 3-fluoro-4-(trifluoromethoxy)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.94 min.; [M+H]+: 427.98 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-a8ffbe65229348049049ab934fccdf6d
Source noteuspto-grants-2016_01