HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(2,2,2-Trifluoroethoxy)benzaldehyde → 5-(2,6-Dimethoxyphenyl)-3-methyl-1-(3-(2,2,2-trifluoroethoxy)benzyl)pyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(2,2,2-Trifluoroethoxy)benzaldehyde | HCID 4770947 | — |
| Reactant | Ethyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoate | HCID 69085588 | — |
| Product | 5-(2,6-Dimethoxyphenyl)-3-methyl-1-(3-(2,2,2-trifluoroethoxy)benzyl)pyrrolidin-2-one | HCID 69082495 | — |
Reaction Steps
Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoate with 3-(2,2,2-trifluoroethoxy)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.90 min.; [M+H]+: 424.43 g/mol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242970B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-8a91e520e0a3481f97315bf4378cf23e |
| Source note | uspto-grants-2016_01 |