Cesium carbonate → HCID 86695668, compound

Participants

Reaction Steps

A mixture of rac-(3R*,5S*)-5-(2-fluoro-6-hydroxyphenyl)-3-hydroxy-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-one (50 mg; 0.13 mmol), 1-fluoro-2-iodoethane (23 mg; 0.13 mmol), potassium carbonate (36 mg; 0.26 mmol), and cesium carbonate (8.5 mg; 0.026 mmol) in anh. DMF (1.3 ml) was stirred at rt, under nitrogen, for 72 h. Filtration of the reaction mixture, and subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.79 min.; [M+H]+: 431.96 g/mol.

Provenance & Evidence