反应详情

1,3-Dihydro-2-benzofuran-5-amine (300 mg, 2.2 mmol) was added to HCOOH (10 mL), and the reaction was stirred at reflux overnight. The reaction was concentrated, basified to pH=8 with sat Na2CO3, and extracted with EtOAc. Organics were washed with brine, dried (Na2SO4), and concentrated to give 250 mg (69%) of N-(1,3-dihydro-2-benzofuran-5-yl)formamide as a yellow oil.

1. temperatureat reflux overnight
2. concentrationThe reaction was concentrated
3. extractionextracted with EtOAc
4. washOrganics were washed with brine
5. dry with materialdried (Na2SO4)
6. concentrationconcentrated