HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → N-(4-cyclopropylphenyl)-2-methoxyacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methoxyacetyl chloride | HCID 96623 | — |
| Reactant | 4-Cyclopropylaniline | HCID 12253927 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(4-cyclopropylphenyl)-2-methoxyacetamide | HCID 118597819 | — |
Reaction Steps
Methoxyacetyl chloride (0.55 mL, 6.0 mmol) was added to a solution of 4-cyclopropylaniline (800 mg, 6.0 mmol) and DIEA (1.05 mL, 6.0 mmol) in DCM, and the reaction was stirred at r.t. for 2 h. The reaction was washed with brine, dried (MgSO4), and concentrated to give crude N-(4-cyclopropylphenyl)-2-methoxyacetamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242968B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-5027ba999f8848178b2fc83f7138e439 |
| Source note | uspto-grants-2016_01 |