Water → HCID 73507392, compound

Participants

Reaction Steps

2-((S)-3-((R)-2-(4-(Cyclopropylsulfonyl)phenyl)-3-((5-fluorothiazol-2-yl)amino)-3-oxopropyl)pyrrolidin-1-yl)-2-oxoethyl acetate (47.0 mg, 89.8 μmol) was dissolved in tetrahydrofuran (1 mL) and methanol (1 mL), and thereafter, an aqueous solution of sodium hydroxide (2 M, 0.36 mL) was added to the obtained solution under ice-cold condition. The obtained mixture was stirred for 30 minutes. Thereafter, water was added to the reaction solution, and the mixed solution was then extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, and was then concentrated in vacuo. The obtained residue was purified by silica gel chromatography (chloroform/methanol=1%→15%) to obtain the captioned compound (38.2 mg, 88%) in the form of a white solid.

Provenance & Evidence