HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → Mellein
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Potassium Permanganate | HCID 516875 | — |
| Reactant | 3,5-Bis(1,1-dimethylethyl)-4-hydroxy-N-octadecylbenzenepropanamide | HCID 19736307 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Product | Mellein | HCID 28516 | — |
Reaction Steps
To a stirred solution of AO-1 (16.5 g, 83.0 mmol) in AcOH (150 mL) kept below 10° C. is added a solution of KMnO4 (14.5 g, 92.0 mmol) in H2O (150 mL) dropwise. The reaction mixture is stirred for 30 min. The mixture is diluted with water, basified by addition of saturated aq Na2CO3 and extracted with EtOAc. The solution is concentrated and the residue is purified by SFC to yield AO-2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242989B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-d400661187fc4bccad7895e0d676b0bc |
| Source note | uspto-grants-2016_01 |