Disodium 1-amino-4-((3-amino-4-sulfophenyl)amino)-9,10-dihydro-9 → HCID 23670489, compound

Participants

Reaction Steps

To a suspension of AQ-1 (51.5 g, 343 mmol) in AcOH (500 mL) is added a solution of KMnO4 (59.7 g, 36.6 mmol) in H2O (500.0 mL) dropwise at 5° C. The reaction mixture is then stirred at rt for 1 h. The mixture is extracted with EtOAc, washed with aq. NaHCO3, dried (Na2SO4) and concentrated. The resultant residue is purified by recrystallization to yield AQ-2.

Provenance & Evidence