反应详情

To a mixture of tert-butyl 3-isonicotinoyl-4-oxopiperidine-1-carboxylate (7.4 g, 24.3 mmol) and TEA (10.15 ml) in ethanol was added hydrazine (3.65 ml, 73 mmol). The reaction mixture was stirred at room temperature for overnight. The solvent was removed under vacuum and DCM (50 ml) was added, followed by water (50 ml). The organic layer was collected, washed with brine and dried over sodium sulfate. Removal of solvent gave the desired product (7 g). LC-MS found 301.2 (M+H)

1. customThe solvent was removed under vacuum and DCM (50 ml)
2. additionwas added
3. customThe organic layer was collected
4. washwashed with brine
5. dry with materialdried over sodium sulfate
6. customRemoval of solvent