Diisopropylethylamine → HCID 66807076, compound

Participants

Reaction Steps

To a solution of (R)-tert-butyl 3-aminopiperidine-1-carboxylate (1 g, 5 mmol) and DIEA (1.76 ml) in DCM (10 ml) at 0° C. was added isopropenyl chloroformate dropwise. After the addition, the reaction mixture was allowed to warm up to room temperature and was stirred for 30 minutes. Saturated sodium bicarbonate solution (10 ml) was added and the organic layer was collected, washed with water and dried over sodium sulfate. After removal of solvent, the crude product (1.8 g) was used directly for the next step reaction.

Provenance & Evidence