Lithium Hydroxide → HCID 66803271, compound

Participants

Reaction Steps

To methyl 1-tert-butyl-3-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indazole-5-carboxylate (1.6 g, 5 mmol) in THF (20 mL) was added LiOH (1 M, 10 mL, 10 mmol) and the reaction was stirred at room temperature for overnight. After removal of THF, HCl (1 N) was added until pH 4 to 5. The product precipitated as white solid and was collected by filtration (1.2 g). LC-MS found 300.2 (M+H)

Provenance & Evidence