Water → HCID 86689213, compound

Participants

Reaction Conditions

Reaction Steps

To methyl 1-tert-butyl-3-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indazole-5-carboxylate (1.6 g, 5 mmol) in dry THF (20 mL) at −78° C. was added LDA (2 M, 5.5 mmol). The reaction temperature was increase to −25° C. for 1 h and was then cooled down to −78° C., MeI (16 mmol) was added and stood at r.t. for overnight, 20 ml water was added, most of the solvent was removed by distillation and the product was extracted with ethyl acetate, purified using silica chromatography (ethyl acetate/hexane) to give the desired product as yellow solid (1.1 g). LC-MS found 328.2 (M+H)

Provenance & Evidence