Methanesulfonyl chloride → HCID 86689214, compound

Participants

Reaction Steps

Methanesulfonyl chloride (1.2 g, 10.6 mmol) was added dropwise to a solution of 8-tert-butyl 2-methyl 3-hydroxy-8-azabicyclo[3.2.1]octane-2,8-dicarboxylate (5.29 mmol) and diisopropylethylamine (3.42 g, 26.5 mmol) in dichloromethane (25 ml) at 0° C. The reaction mixture was warmed to room temperature and stirred for 16 h. Dichloromethane (50 ml) was added and washed with saturated sodium bicarbonate solution (50 ml) and brine solution (50 ml). The organic layer was separated, and dried over sodium sulfate. The solution was filtered, concentrated, and used in the next step without further purification.

Provenance & Evidence