Triethylamine → HCID 86689215, compound

Participants

Reaction Conditions

Reaction Steps

Diphenylphosphoryl azide (890 mg, 3.23 mmol) was added into a solution of 8-(tert-butoxycarbonyl)-8-azabicyclo[3.2.1]octane-2-carboxylic acid (0.75 g, 2.94 mmol) and triethylamine (595 mg, 5.88 mmol) in toluene (10 ml). The reaction solution was heated at 100° C. for 5 h. EtOAc (50 ml) was added and the resulting solution was washed with water (10 ml). The organic layer was separated, and dried over sodium sulfate. The solution was filtered, concentrated, and used in the next step without further purification.

Provenance & Evidence