Diisopropylethylamine → HCID 86689216, compound

Participants

Reaction Conditions

Reaction Steps

Dimethylformamide (0.7133 mL) was added to a flask containing 3-(1-methyl-1H-indazol-5-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine (54.2 mg, 0.214 mmol) and tert-butyl 2-isocyanato-8-azabicyclo[3.2.1]octane-8-carboxylate (45 mg, 0.178 mmol). Diisopropylethylamine (0.1474 mL, 0.856 mmoL) was added to the flask, and the reaction was allowed to stir at 70° C. for 16 hrs. The reaction was quenched with water and was extracted using ethyl acetate three times. The ethyl acetate layers were combined, dried over sodium sulfate, filtered, and concentrated. The crude was purified using flash chromatography (methanol in dichloromethane 0-20%).

Provenance & Evidence