Hydrochloric Acid → HCID 52914753, compound

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Reaction Steps

A solution of methyl 2-((6-(1-methyl-1H-pyrazol-4-ylamino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)benzoate (15 mg, 0.04 mmol) and sodium hydroxide (1 mL, 4M aqueous solution) in THF (3 mL) was stirred at rt for 2 h. The mixture was then acidified with HCl (2M) and extracted into EtOAc. The organic phase was collected, dried (MgSO4) and concentrated in vacuo to give the title product. 1H NMR (d6-DMSO) δ 9.86 (s, 1H), 8.94 (s, 1H), 8.11 (s, 1H), 7.93 (d, 1H), 7.89 (s, 1H), 7.47 (s, 1H), 7.36-7.41 (m, 2H), 6.79 (s, 1H), 5.95 (s, 2H), 3.78 (s, 3H); LC-MS method B, (ES+) 350.0, RT=6.91 min.

Provenance & Evidence