1-(Bromomethyl)-2,3-dichlorobenzene → HCID 67113576, compound

HRID 594980Notes

Reaction equation

HRID 594980 reaction equation
Br[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([Cl:9])[C:4]=1[Cl:10].Cl[C:12]1[N:17]=[C:16]2[NH:18][N:19]=[CH:20][C:15]2=[CH:14][N:13]=1.[CH3:21][N:22]1[CH:26]=[C:25]([NH2:27])[CH:24]=[N:23]1>>[Cl:10][C:4]1[C:5]([Cl:9])=[CH:6][CH:7]=[CH:8][C:3]=1[CH2:2][N:18]1[C:16]2=[N:17][C:12]([NH:27][C:25]3[CH:24]=[N:23][N:22]([CH3:21])[CH:26]=3)=[N:13][CH:14]=[C:15]2[CH:20]=[N:19]1

Participants

4

Reactant 3

HCID 27346021-(Bromomethyl)-2,3-dichlorobenzeneHCID 47709901-methyl-1H-pyrazol-4-amineHCID 529112546-chloro-1H-pyrazolo[3,4-d]pyrimidine

Product 1

HCID 67113576HCID 67113576, compound

Procedure

The following compound was made according to the procedures in Example 1 (Step ii) using 1-(bromomethyl)-2,3-dichlorobenzene and 6-chloro-1H-pyrazolo[3,4-d]pyrimidine, followed by Example 1 (Step i) using 1-methyl-1H-pyrazol-4-amine.

Sources & evidence

ORD record
ord-06a8688fc1384d00a1971c73d8423086
Source dataset
uspto-grants-2016_01
Patent number
US09242987B2

Reaction notes

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