Diisobutylaluminum hydride → HCID 67112208, compound

Participants

Reaction Steps

To a solution of 2-methoxyethyl 3-(2-methoxyethoxy)-2-methylbenzoate (0.83 g, 3.1 mmol) in DCM (50 mL) at 0° C. was added DIBAL (1M in THF, 13.6 mL, 4.4 eq) dropwise under inert atmosphere. After stirring for 24 h at rt, the reaction was quenched with saturated ammonium chloride until dissolution of the jelly precipitate. The aqueous phase was extracted with DCM, and the combined organic phases dried over sodium sulfate and concentrated in vacuo to afford (3-(2-methoxyethoxy)-2-methylphenyl)methanol in a quantitative yield.

Provenance & Evidence