Borane → HCID 86671736, compound

Participants

Reaction Steps

A solution of 3-Amino-2,5,6-trifluoro benzoic acid (500 mg, 2.6 mmol) in THF (4 mL) was cooled to 0° C. (ice bath). Borane (2.5 eq., 1M in THF) was added dropwise over 20 min. The reaction was allowed to warm slowly to rt and stirred at rt for 18 h. The reaction was quenched by addition of saturated NH4Cl (aq) and extracted with EtOAc. The organic phase was washed with H2O then brine, dried (Na2SO4), filtered and concentrated in vacuo to give (3-amino-2,5,6-trifluorophenyl)methanol as a pale brown solid (425 mg, 92%)

Provenance & Evidence