Borane → HCID 86671745, compound

Participants

Reaction Steps

3-(4-(tert-butoxycarbonyl)piperazin-1-yl)-2,5,6-trifluorobenzoic acid (0.84 g) was reacted in the standard reduction conditions with Borane in THF (see Example 179, Step i). The crude product was purified by Flash chromatography using a gradient of Hexane/Ethyl acetate (from 9:1 to 1:4) to give tert-butyl 4-(2,4,5-trifluoro-3-(hydroxymethyl)phenyl)piperazine-1-carboxylate as a white solid (0.18 g, 37% yield from beginning of step ii)

Provenance & Evidence