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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 595018Generated: October 29, 2026

tert-Butyl piperazine-1-carboxylate → 1-Piperazinecarboxylic acid, 4-(3-carboxy-2-fluorophenyl)-, 1-(1,1-dimethylethyl) ester

https://huagongshe.com/reaction/595018

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl piperazine-1-carboxylateHCID 143452—
Reactant3-Bromo-2-fluorobenzoic acidHCID 2736313—
Product1-Piperazinecarboxylic acid, 4-(3-carboxy-2-fluorophenyl)-, 1-(1,1-dimethylethyl) esterHCID 66765352—

Reaction Steps

3-(4-(tert-butoxycarbonyl)piperazin-1-yl)-2-fluorobenzoic acid was synthesised following the procedure in Example 162 (Step ii) using 3-bromo-2-fluorobenzoic acid and tert-butyl piperazine-1-carboxylate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242987B2
Source datasetuspto-grants-2016_01
ORD IDord-4b1604a21b6b4c9893cbad88709acb3e
Source noteuspto-grants-2016_01