tert-Butyl piperazine-1-carboxylate → HCID 67112443, compound

HRID 595023Notes

Reaction equation

HRID 595023 reaction equation
Br[C:2]1[C:3]([F:12])=[C:4]([C:8]([F:11])=[CH:9][CH:10]=1)[C:5]([OH:7])=[O:6].[N:13]1([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>>[C:22]([O:21][C:19]([N:13]1[CH2:18][CH2:17][N:16]([C:2]2[C:3]([F:12])=[C:4]([C:8]([F:11])=[CH:9][CH:10]=2)[C:5]([OH:7])=[O:6])[CH2:15][CH2:14]1)=[O:20])([CH3:25])([CH3:23])[CH3:24]

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 144915963-Bromo-2,6-difluorobenzoic acid

Product 1

HCID 67112443HCID 67112443, compound

Procedure

3-(4-(tert-butoxycarbonyl)piperazin-1-yl)-2,6-difluorobenzoic acid was prepared as in Example 162 (Step ii) using 3-bromo-2,6-difluorobenzoic acid and tert-butyl piperazine-1-carboxylate.

Sources & evidence

ORD record
ord-f727434aab384a9f98c9482e3f321632
Source dataset
uspto-grants-2016_01
Patent number
US09242987B2

Reaction notes

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