HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine → tert-butyl 4-(2,4-difluoro-3-((6-((1-methyl-1H-pyrazol-4-yl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)phenyl)piperazine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine | HCID 66765655 | — |
| Reactant | Tert-butyl 4-(2,4-difluoro-3-(((methylsulfonyl)oxy)methyl)phenyl)piperazine-1-carboxylate | HCID 86671748 | — |
| Product | tert-butyl 4-(2,4-difluoro-3-((6-((1-methyl-1H-pyrazol-4-yl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)phenyl)piperazine-1-carboxylate | HCID 68378868 | — |
Reaction Steps
tert-butyl 4-(2,4-difluoro-3-((6-((1-methyl-1H-pyrazol-4-yl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)phenyl)piperazine-1-carboxylate was synthesized following the procedure in Example 1 (Step i) then Step (ii) using tert-butyl 4-(2,4-difluoro-3-(((methylsulfonyl)oxy)methyl)phenyl)piperazine-1-carboxylate and N-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242987B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-984ac3dbc0564cc785c00889b2df9da6 |
| Source note | uspto-grants-2016_01 |