N-Cyclopropyl-N'-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea → HCID 71548516, compound

HRID 595077Notes

Reaction equation

HRID 595077 reaction equation
Cl[C:2]1[N:3]=[C:4]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][C@@H:16]2[CH3:21])[C:5]2[CH2:10][S:9](=[O:12])(=[O:11])[C:8]([F:14])([CH3:13])[C:6]=2[N:7]=1.[CH:22]1([NH:25][C:26]([NH:28][C:29]2[CH:34]=[CH:33][C:32](B3OC(C)(C)C(C)(C)O3)=[CH:31][CH:30]=2)=[O:27])[CH2:24][CH2:23]1>>[CH:22]1([NH:25][C:26]([NH:28][C:29]2[CH:34]=[CH:33][C:32]([C:2]3[N:3]=[C:4]([N:15]4[CH2:20][CH2:19][O:18][CH2:17][C@@H:16]4[CH3:21])[C:5]4[CH2:10][S:9](=[O:12])(=[O:11])[C:8]([F:14])([CH3:13])[C:6]=4[N:7]=3)=[CH:31][CH:30]=2)=[O:27])[CH2:24][CH2:23]1

Participants

3

Reactant 2

HCID 44119149N-Cyclopropyl-N'-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ureaHCID 89487647HCID 89487647, compound

Product 1

HCID 71548516HCID 71548516, compound

Procedure

The title compound was synthesised following the procedure in Example 5 (step viii) using 2-chloro-7-fluoro-7-methyl-4-((S)-3-methylmorpholino)-5,7-dihydrothieno[3,4-d]pyrimidine 6,6-dioxide and 1-cyclopropyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea.

Sources & evidence

ORD record
ord-4f08fbe710b14bca94a5df77c6010cc2
Source dataset
uspto-grants-2016_01
Patent number
US09242993B2

Reaction notes

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