HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → (5-Chlorocarbonyl-pyridin-2-yl)-ethyl-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | 6-(((Tert-butoxy)carbonyl)(ethyl)amino)pyridine-3-carboxylic acid | HCID 66769552 | — |
| Product | (5-Chlorocarbonyl-pyridin-2-yl)-ethyl-carbamic acid tert-butyl ester | HCID 86664610 | — |
Reaction Steps
6-(tert-Butoxycarbonyl-ethyl-amino)-nicotinic acid (6.40 g, 24.0 mmol) is taken up in 150 mL DCE, 1-chloro-N,N-2-trimethylpropenyl-amine (6.42 mL, 48.1 mmol) is added and the reaction mixture is stirred overnight at RT. The reaction mixture is concentrated under reduced pressure and the crude product is used in the next step without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09243000B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-068c5445f3374fb9b532cbba1e893995 |
| Source note | uspto-grants-2016_01 |