N-(5-methyl-7-oxo-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)acetamide → [5-(2-Acetylamino-5-methyl-7-oxo-4,5,6,7-tetrahydro-benzothiazole-6-carbonyl)-pyridin-2-yl]-methyl-carbamic acid tert-butyl ester

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Reaction Steps

A-13 is prepared via general procedure A1 starting from (5-chlorocarbonyl-pyridin-2-yl)-methyl-carbamic acid tert-butyl ester (A-10) (7.24 g, 26.8 mmol) and N-(5-methyl-7-oxo-4,5,6,7-tetrahydro-benzothiazol-2-yl)-acetamide (A-06) (5.00 g, 22.3 mmol). After evaporation of the solvent 7.72 g of A-13 is obtained that is used without further purification in the next step.

Provenance & Evidence