N-(5-methyl-7-oxo-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)acetamide → [5-(2-Acetylamino-5-methyl-7-oxo-4,5,6,7-tetrahydro-benzothiazole-6-carbonyl)-pyridin-2-yl]-ethyl-carbamic acid tert-butyl ester

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Reaction Steps

A-14 is prepared via general procedure A1 starting from (5-chlorocarbonyl-pyridin-2-yl)-ethyl-carbamic acid tert-butyl ester (A-09) (7.62 g, 26.8 mmol) and N-(5-methyl-7-oxo-4,5,6,7-tetrahydro-benzothiazol-2-yl)-acetamide (A-06) (5.00 g, 22.3 mmol). After evaporation of the solvent 8.62 g of A-14 are obtained which is used without further purification in the next step.

Provenance & Evidence