Chloroacetaldehyde → HCID 90427811, compound

HRID 595125Notes

Reaction equation

HRID 595125 reaction equation
[NH2:1][C:2]1[N:9]=[C:8]([CH3:10])[CH:7]=[C:6]([CH3:11])[C:3]=1[C:4]#[N:5].Cl[CH2:13][CH:14]=O>O>[CH3:10][C:8]1[N:9]2[CH:13]=[CH:14][N:1]=[C:2]2[C:3]([C:4]#[N:5])=[C:6]([CH3:11])[CH:7]=1

Participants

4

Reactant 2

HCID 33ChloroacetaldehydeHCID 2304712-Amino-4,6-dimethyl-3-pyridinecarbonitrile

Product 1

HCID 90427811HCID 90427811, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

To a stirred solution of compound 2-amino-4,6-dimethylnicotinonitrile (1 equiv.) in water was added chloroacetaldehyde (55% aq. solution) (1.2 equiv.) and reaction was heated at 80° C. for 16 h. On completion, it was quenched by 1N NaOH till pH 8. Solid precipitated was filtered and vacuum dried to afford the title compound (75% yield).

Workup

  1. customOn completion, it was quenched by 1N NaOH till pH 8
  2. customSolid precipitated
  3. filtrationwas filtered
  4. customvacuum dried

Sources & evidence

ORD record
ord-406b2916140c43b5b7e1954cbde28cbd
Source dataset
uspto-grants-2016_01
Patent number
US09243001B2

Reaction notes

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