HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 90427644, compound → HCID 90426211, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 90427644 | HCID 90427644 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ammonia | HCID 222 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 90426211 | HCID 90426211 | — |
Reaction Steps
To a solution of 2,4-dimethyl-2H-indazole-7-carbonitrile (1 equiv.) in methanol and aq. ammonia solution (9:1), catalytic amount of Raney Nickel was added. Reaction mass was stirred at room temperature under hydrogen pressure (balloon pressure) for 2-5 h. On completion of reaction, it was filtered through celite bed and filtrate was concentrated under reduce pressure to afford the title compound (quant. yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09243001B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-c4e6dfd551b04945bef3113ecc9db722 |
| Source note | uspto-grants-2016_01 |