反应详情

温度

0 °C

To a stirred solution of 4-acetyl-1-(2,4-dimethoxybenzyl)pyrrolidin-2-one (1.5 g, 7.2 mmol) in MeOH (15 mL), NaBH4 (400 mg, 10.8 mmol) was added at 0° C. The reaction mixture was stirred at 0° C. for 1 hour then diluted with water and extracted with EtOAc. The organic layers were dried over sodium sulfate and concentrated under reduced pressure to afford 1-(2,4-dimethoxybenzyl)-4-(1-hydroxyethyl)pyrrolidin-2-one. 1H NMR (400 MHz, CDCl3) δ 7.10-7.13 (m, 1H), 6.43-6.45 (m, 2H), 4.41-4.42 (m, 2H), 3.79-3.82 (m, 6H), 3.67-3.70 (m, 1H), 3.06-3.46 (m, 2H), 2.03-2.50 (m, 3H), 1.26-1.42 (d, J=7.2 Hz, 3H). MS ESI calc'd. for C15H22NO4 [M+H]+ 280. found 280.

1. extractionextracted with EtOAc
2. dry with materialThe organic layers were dried over sodium sulfate
3. concentrationconcentrated under reduced pressure