Urea → HCID 118208568, compound

Participants

Reaction Steps

The solution of 2-((4-iodo-1H-pyrazol-1-yl)methyl)succinic acid (170 mg, 0.52 mmol) and urea (72 mg, 1.50 mmol) was stirred neat at 130° C. for 12 hours. After cooling to room temperature, the mixture was diluted with water and extracted with EtOAc. The organic layer was dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to afford 3-((4-iodo-1H-pyrazol-1-yl)methyl)pyrrolidine-2,5-dione. MS ESI calc'd. for C8H9IN3O2 [M+H]+ 306. found 306. 1H NMR (400 MHz, CD3OD) δ 7.70 (s, 1H), 7.50 (s, 1H), 4.62-4.43 (m, 2H), 3.48-3.37 (m, 1H), 2.85-2.68 (m, 1H), 2.61-2.49 (m, 1H).

Provenance & Evidence