反应详情

温度

60 °C

A mixture of methyl 2-hydroxy-3-(4-iodo-1H-pyrazol-1-yl)propanoate (4 g, 13 mmol) and ammonia (saturated in methanol, 100 mL) in a sealed tube was stirred at 60° C. for 12 hours. After cooling to room temperature, the mixture was concentrated under reduced pressure to afford 2-hydroxy-3-(4-iodo-1H-pyrazol-1-yl)propanamide. MS ESI calc'd. for C6H9IN3O2 [M+H]+ 282. found 282. 1H NMR (400 MHz, CDCl3) δ 7.72 (s, 1H), 7.50 (s, 1H), 4.53-4.49 (m, 1H), 4.36-4.29 (m, 2H).

1. temperatureAfter cooling to room temperature
2. concentrationthe mixture was concentrated under reduced pressure