Ammonium Chloride → HCID 13567484, compound

Participants

Reaction Steps

Sodium borohydride (0.55 g, 14.65 mmol) was added to a mixture of (4S,5R)-methyl 5-methyl-2-oxooxazolidine-4-carboxylate (2.12 g, 13.32 mmol) in ethanol (29 mL) at 0° C. The mixture was stirred for 3 hours and then 2 mL of saturated aqueous ammonium chloride was added. The mixture was stirred for 30 minutes and the white solids were filtered through CELITE and the filter cake was washed with ethanol. The filtrate was concentrated under reduced pressure and dried under vacuum to afford (4R,5R)-4-(hydroxymethyl)-5-methyloxazolidin-2-one. 1H NMR (500 MHz, D2O) δ 4.56-4.37 (m, 1H), 3.60-3.38 (m, 3H), 1.27 (d, J=6.4 Hz, 3H).

Provenance & Evidence